OBTAINING AND RESEARCH OF PALLADIUM COMPLEXES WITH 4-AMINOPIRIDINE

Abstract

The obtaining and investigation of various complex compounds of the biologically active aromatic heterocyclic ligands with platinum and palladium are of interest due to their potential medical applications. To that end, 4-amino pyridine containing cyclic and exocyclic nitrogen atoms has been used. The main aim of this work is to clarify which nitrogen atom of the ligand composes stronger and more stable bond. As a result of IR-spectroscopic investigation of synthesized complexes, the acquired information demonstrated that the pyridine nitrogen atom of the ligand is protonated and composes outer sphere as monocharged cation. However, tetraacidoanion is formed in the inner sphere. In the alkaline medium the ligand is monodentately coordinated with palladium through nitrogen atom of pyridine. The exocyclic nitrogen atom of the ligand does not participate in the coordination regardless of pH of the medium and stoichiometric ratio of the taken compounds The initial biological probes were accomplished and the correlation between their biological activities, composition and structures of complexes were determined.