Observer-Based Control of LPV Systems with Input Delay and Saturation and Matched Disturbances via a Generalized Sector Condition

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This paper examines the control design for parameter-dependent input-delay linear parameter-varying (LPV) systems with saturation constraints and matched input disturbances. A gain-scheduled dynamic output feedback controller, coupled with a disturbance observer to cancel out input disturbance effects, was augmented with an anti-windup compensator to locally stabilize the input-delay LPV system under saturation, model uncertainty, and exogenous disturbances. Sufficient delay-dependent conditions to asymptotically stabilize the closed-loop system were derived using Lyapunov-Krasovskii functionals and a modified generalized sector condition to address the input saturation nonlinearity. The level of disturbance rejection was characterized via the closed-loop inducedL2-norm of the closed-loop system in the form of linear matrix inequality (LMI) constraints. The results are examined in the context of the mean arterial pressure (MAP) control in the clinical resuscitation of critical hypotensive patients. The MAP variation response to the injection of vasopressor drugs was modeled as an LPV system with a varying input delay and was susceptible to model uncertainty and input/output disturbances. A Bayesian filtering method known as the cubature Kalman filter (CKF) was used to estimate the instantaneous values of the parameters. The varying delay was estimated via a multiple-model approach. The proposed input-delay LPV control was validated in closed-loop simulations to demonstrate its merits and capabilities in the presence of drug administration constraints.