Abstract
IT has been adequately demonstrated that the basic defect in pernicious anemia is failure of the mucosal cells in the fundal portion of the stomach to secrete intrinsic-factor substance. This factor is necessary for normal absorption of vitamin B12 from the small intestine. A few reports in the literature have shown suboptimal reticulocyte responses in patients with pernicious anemia in relapse receiving ACTH and cortisone.1 2 3 4 We have recently studied the effect of adrenocortical-steroid administration on the absorption of radioactive vitamin B12 in classic primary pernicious anemia utilizing the Schilling test, which measures the absorption of orally administered radioactive . . .
Published Version
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