Abstract

SUMMARY An autoradiographic, histochemical and ultrastructural study of the rabbit placenta at Day 15 and 25 was undertaken in an attempt to correlate structural changes in the placental barrier with increases in iron transfer. Attenuation of the chorionic epithelium in the 25-day placenta is described, at which time autoradiographs show the presence of grains in the maternal blood spaces, along the chorionic epithelium, and in the foetal capillaries. Histochemical results gape a similar picture. At 15 days, autoradiography and histochemistry gave negative results. It is suggested that iron is carried to the surface of the trophoblast lining the maternal blood space, transferred to a receptor within the trophoblast and from thence to the foetal blood.

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