Observation on the clinical curative effect of praziquantel, mebendazole, albendazole, triclabendazole treatment on Fasciola gigantica disease

Abstract

Objective To investigate the therapeutic effect of praziquantel,mebendazole,albendazole or triclabendazole on Fasciola gigantica disease by clinical comparative method. Methods 18 cases of Fasciola gigantica were treated respectively with mebendazole tablets [ 5 mg/( kg · d),2 times a day orally,for 15 d ],albendazole tablets [ (20 mg/(kg · d),2 times a day orally,for 15 d ],triclabendazole [ 10mg/(kg · d) meal service,two days a course of treatment].3 of the 18 cases were given a total dose of praziquantel 120 ～180 mg/kg,equally divided into 4 d,twice a day.The curative effects were assessed after the completion of treatment,according to the evaluation criteria:( 1 ) after a course of treatment,the clinical symptoms were significantly alleviated,especially the frequency and severity of fever had obviously improved than that before treatment.(2) Count of white blood cells and count or proportion of eosinophils decreased than that before treatment,and erythrocyte sedimentation rate,C-reactive protein and other inflammatory response reduced compared to that before treatment.(3) Liver CT should be re-examined half an month after treatment,low density foci were absorpted compared to that before treatment. (4) Feces discharged was free of eggs of Fasciola gigantica.Significant effect must meet the four standards of (1),(2),( 3 ),(4).Valid'effect must meet the criteria ( 1 ),plus,the arbitrary two of ( 2 ) or ( 3 ) or ( 4 ).Invalid does not meet anyone of ( 1 ),(2),( 3 ),(4).Results Praziquantel,mebendazole,or albendazole treatment on Fasciola gigantica disease was invalid,while triclabendazole treatment of 18 cases of Fasciola hepatica disease was effective.Conclusion Triclabendazole was effective for treatment of Fasciola gigantica disease. Key words: Praziquantel ; Mebendazole ; Albendazole ; Triclabendazole ; Fasciola gigantica disease ; Curative effect ;