Observation on curative effect of recombinant human granulocyte-macrophage colony stimulation factor in the treatment of oral ulcer after chemotherapy in acute leukaemia patients

Abstract

Objective To evaluate the curative effect of recombinant human granulocyte-macrophage colony stimulation factor(rhGM-CSF)on oral ulcer after chemotherapy in adult acute leukaemia patients. Methods From June 2013 to August 2015, 52 adult acute leukaemia patients with oral ulcer after chemotherapy were divided into treatment group and control group according to randomized controlled method, with 26 cases in each group. The treatment group was treated with rhGM-CSF plus 100 ml sodium chloride injection with gargling administration and put it in a refrigeration, 20 ml each time, 5 times daily (fasting in the morning, 0.5 h after meals and at bedtime), 5 min for each gargling at least. The control group was treated by traditional method. Both groups were given treatment from the occurrence of oral ulcer within 24 hours until oral ulcer healing or completing 1 week of mouth nursing. The overall response rate of oral ulcer healing, the time of average healing time of oral ulcer, and the incidence of adverse reactions were observed and recorded. Results In treatment group, the response rate of oral ulcer healing was 80.8%, while in control group it was only 46.2% (P<0.05). The average healing time of oral ulcer in treatment group was significantly shorter than that in control group[(6.42±2.16)d vs. (9.19±2.42) d, P<0.01], treating and there was no adverse reaction occurred. Conclusions The efficacy of rhGM-CSF collutory on chemotherapy-induced oral ulcer is satisfactory in adult acute leukaemia patients. It can effectively reduce the severities of oral pain and the time of alleviating pain, and obviously shorten the healing time of oral ulcer, so it is worthy of clinical popularization and application. Key words: Recombinant human granulocyte-macrophage colony stimulation factor; Acute leukaemia; Oral ulcer; Curative effect