Observation on Carboprost Tromethamine and Oxytocin for Reduction of Hemorrhage in Caesarean Section

Abstract

Objective To observe the effect of carboprost tromethamine (hemabate) and oxytocin in cesarean section for preventing and reducing the intraoperative bleeding and compare their adverse reaction. Methods From November 2013 to March 2014, a total of 40 parturient women underwent cesarean section were included in the study.They were randomly divided into groupⅠ(20 cases using carboprost tromethamine injection) and groupⅡ (20 cases using oxytocin) according to different drugs for the injection into their uterine corpus immediately after fetal disengagement.There were no significant differences in maternal age, gestational age, body weight in general between two groups ( P>0.05). The study protocol was approved by the Ethical Review Board of Investigation in Human Being of Shanghai First Maternity and Infant Hospital.Informed consent was obtained from each participants. Results The amount of blood loss during cesarean section in groupⅠwas obviously lower than that of groupⅡ(P<0.05). There were significant differences in vital signs at 10 min after treatment between two groups(P<0.05). The incidence rate of adverse reaction in groupⅠ was significantly higher than that of groupⅡ (P<0.01). Conclusion Carboprost tromethamine injection in caesarean operation can effectively decrease the intraoperative bleeding, but more attention should be paid on its adverse reaction. Key words: Hemorrhage; Cesarean section; Carboprost tromethamine