Intra-uterus injection of carboprost tromethamine during cesarean section in prevention of postpartum hemorrhage

Abstract

Objective To explore the effect of intra-uterus injection of carboprost tromethamine during cesarean section in the prevention of postpartum hemorrhage. Methods 80 puerperae with high risk of postpartum hemorrhage admitted into our hospital from January, 2013 to May, 2014 were selected and randomly divided into an experimental group and a control group, 40 cases for each group. The control group took oxytocin, misoprostol, pituitary hormone, and calcium gluconate and the experimental group oxytocin and carboprost tromethamine. The bleeding volume and treatment effect were observed and compared between these two groups. Results The intra-operation bleeding volume [(257.9±76.4)ml vs. (388.7±90.1) ml], bleeding volume 2 hours after delivery [(101.7±29.7) ml vs. (198.6±34.9) ml], and bleeding volume 24 hours after delivery [(299.8±68.4)ml vs. (488.6±59.3) ml] were significantly less in the experimental group than in the control group (P<0.05). The hemostatic time was (18.7±12.1) min in the experimental group and was (45.6±16.2) min in the control group, with a statistical difference (P<0.05). 3 cases needed blood transfusion and none needed hysterectomy in the experimental group and 12 and 2 in the control group (P<0.05). Conclusions Intra-uterus injection of carboprost tromethamine during cesarean section in the prevention of postpartum hemorrhage is effective and worth being clinically generalized. Key words: Cesarean section; Carboprost tromethamine; Postpartum hemorrhage