Observation of the efficacy of femtosecond laser small incision lenticule extraction(SMILE) for myopia

Abstract

Objective To observe the long-term efficacy of intravitreal injection of Conbercept before trabeculectomy combined with panretinal photocoagulation (PRP) in the treatment of neovascular glaucoma (NVG). Methods The data of 30 eyes of 30 NVG patients from Jan.2014 to Dec.2014 were collected and analyzed retrospectively. All cases were treated with intravitreal injection of Conbercerpt. After neovessels of iris disappeared, they underwent trabeculectomy combined with PRP. The follow-up time was 30 months. The visual acuity, intraocular pressure, iris neovascular vessels and complications were observed after operation. Results Iris neovascular vessels disappeared in 27 eyes (90.00%) after 3-7 days intravitreal injection of Conbercerpt. Iris neovascular vessels reduced significantly in 3 eyes 3 days after injection and disappeared 10 days after injection. The IOP after treatment decreased significantly from (41.23 ±8.96) mmHg to (15.23±2.91) mmHg (1 mmHg=0.133 kPa). The difference was statistically significant (P<0.05). The IOP was controlled successfully in 26 eyes (86.67%), partly controlled in 4 eyes (13.33%). The best corrected visual acuity improved in 3 eyes (10.00%), no changed in 25 eyes (83.33%)and decreased in 2 eyes (6.67%). No complication related with the intravitreal injection appeared. Hyphema occurred during trabeculectomy in 4 eyes (13.33%), no shallow anterior chamber or vitreous hemorrhage happened after trabeculectomy. Conclusion Intravitreal injection of Conbercept before trabeculectomy combined with PRP postoperatively is safe and effective for NVG.The surgery can control IOP for a long time with high success rate. Key words: Glaucoma, neovascular; Trabeculectomy; Conbercept, intravitreal injection; Photocoagulation, panretinal