Observation of the effect of blood perfusion combined with penehyclidine hydrochloride injection in the treatment of acute severe organophosphorus pesticide poisoning

Abstract

Objective To explore the clinical effect of blood perfusion combined with penehyclidine hydrochloride injection in the treatment of acute severe organophosphorus pesticide poisoning. Methods 58 patients with severe organophosphorus pesticide poisoning were selected as the research subjects.By using digital table method, they were randomly divided into observation group and control group, 29 cases in each group.The two groups were given conventional treatment and blood perfusion treatment after admission, the observation group was treated with penehyclidine hydrochloride injection on this base.Before and after treatment, the myocardial enzymes, liver, kidney function index, blood gas analysis, cholinesterase activity, as well as other treatment of the two groups were observed, and the results were compared. Results Compared with the control group, after treatment, the myocardial enzyme, transaminase, serum amylase and creatinine levels in the observation group were significantly lower, cholinesterase level was significantly increased, the oxygen partial pressure increased, the partial pressure of carbon dioxide decreased obviously, the differences were statistically significant(all P<0.05). The hospitalization time and cholinesterase activity recovery time of the observation group were significantly shorter than those of the control group[(12.57±2.14)d vs.(16.35±2.73)d, (5.46±2.29)d vs.(7.61±3.47)d], and the cure rate of the observation group was significantly higher than that of the control group(100.00% vs.82.76%), the differences were statistically significant(t=2.139, 2.208, χ2=5.472, all P<0.05). Conclusion Blood perfusion can directly adsorb organophosphorus pesticide, shorten the recovery time of cholinesterase and reduce the case fatality rate, and it combined with penehyclidine hydrochloride injection not only can improve the clinical curative effect of blood perfusion, but also can protect the organ. Key words: Poisoning; Pesticides; Organophosphorus compounds; Perfusion; Penehyclidine hydrochloride