Observation of the effect and the influence on PCT,CRP in the treatment of patients with acute exacerbation pulmonary disease by Budesonide and ipratropium bromide

Abstract

Objective To observe the effect and the influence on PCT,CRP in the treatment of patients with acute exacerbation pulmonary disease by Budesonide and ipratropium bromide. Methods 80 patients with acute exacerbation pulmonary disease were randomly divided into 40 cases of the control group and 40 cases of the observation group, the two groups were given routine treatment, the control group then had been given ipratropium bromide for 7d, and the observation group had been given Budesonide and ipratropium bromide for 7d,the blood gas indicators (PaO2,PCO2), pulmonary function(FEV1,PEF,FEV1/FVC),dyspnoea and exercise tolerance score, serum PCT levels, serum CRP levels and clinical efficacy were compared, Adverse reactions were recorded. Results (1)the PaO2, FEV1,PEF,FEV1/FVC of the observation group and the control group after treatment were(70.7±2.3)mm Hg and (62.5±3.0)mm Hg,(2.15±0.63)L and(1.76±0.56)L,(3.49±0.82)L/s and(3.06±0.75)L/s,(68.52±6.53)% and(60.14±6.03)%, These indicators were significantly higher than those before treatment,all P<0.05,the PCO2, PCT,CRP were(51.4±1.7)mm Hg and(56.6±2.3)mm Hg,(1.75±1.20)μg/L and(2.58±1.17)μg/L,(10.25±6.77)mg/L and(19.07±5.75)mg/L,These indicators were significantly lower than those before treatment,all P< 0.05,the PaO2,FEV 1,PEF,FEV 1/FVC of the observation group were significantly higher than those of the control group,the PCO 2,PCT,CRP were significantly lower than those of the control group, all P<0.05;(2)The dyspnoea and exercise tolerance score of the observation group and the control group after treatment was significantly lower than those before treatment, the dyspnoea and exercise tolerance score of the observation group was significantly lower than those of the control group;(3)The clinical total effective rate of the observation group was 90%,which was higher than 65%of the control group(χ2=7.312,P<0.05). Conclusion The method containing Budesonide and ipratropium bromide Inhalation has exact effect, and can effectively improve respiratory function, which is an effective treatment of choice for acute exacerbation of COPD. Key words: Pulmonary disease, chronic obstructive; Budesonide; Compound ipratropium bromide; Procalcitonin; C-reactive protein