Abstract
Spreading cortical depression (SCD) in animal models was first described by Leao [1] in 1944. SCD, although never observed spontaneously in humans, has been implicated in migraine for a variety of reasons: 1) the marked dilation of pial blood vessels accompanying SCD [2], 2) the slow propagation speed of 3 mm/min which is comparable to the motion of migraine scotomata [3] and 3) the cerebral blood flow anomolies observed in migraine with aura which are also similar to those seen during SCD [4]. SCD is not observable by surface EEG, but Okada et al [5, 6] produced SCD in isolated turtle cerebellum by electrical stimulation and recorded biphasic slow magnetic waves. They suggested SCD should be observable by MEG in humans. We report here the results of studies on migraine patients, normal subjects and patients suffering non-migraine headaches.
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