Observation of pranprofen to prevent dry eyes after cataract surgery

Abstract

Objective To observe the preventive effect of pranoprofen on the dry eye after phacoemulsification. Methods The data of 300 eyes of 245 cases with cataract who received phacoemulsification from Jan.2017 to Jan.2018 in Changxing County People’s Hospital were selected and analyzed retrospectively.According to random number table, all cases were divided into two groups. The hyaluronate group, 150 eyes of 123 cases, were treated with sodium hyaluronate eye drops at 3 days before operation and 1 day after operation.And the pranoprofen group, 150 eyes of 122 cases, were treated with pranprofen eye drops combind with sodium hyaluronate eye drops. The ocular inflammation were observed and compared between the two groups. Results At 30 days after operation the tumor necrosis factor-a(TNF-a), interleukin -6(IL-6), high sensitive C-reactive(hs-CRP) and corneal fluorescence staining(FL), aningeresting, foreign body sensation, pain and fatigue scores in pranoprofen group and hyaluronate group were significantly lower than those in 3 days preoperatively.At 30 days after operation the TNF-a, IL-6, hs-CRP and FL, dryness, foreign body sensation, pain and fatigue scores in pranoprofen group were significantly lower than those in hyaluronate group.At 30 days after operation the basic tear secretion test and tear film rupture time in pranprofen group and hyaluronate group were significantly higher than those at 3 days preoperatively. At 30 days after operation the basic tear secretion test and tear film rupture time in pranoprofen group were significantly higher than those in hyaluronate group, the difference were statistically significant (P<0.05). No adverse reaction in two group occurred. Conclusion Pranprofen can effectively amelionate the ocular inflammation and tear film function after phacoemulsification, and it has the good preventive effect on dry eye, and it is safety. Key words: Pranoprofen; Cataract; Phacoemulsification; Dry eye; Prevention