Observation of neuropsychological development status in children after surgical treatment of congenital heart diseases

Abstract

Objective To observe neuropsychological development status in children after surgical treatment of congenital heart diseases(CHDs) and analyze the risk factors. Methods 89 children who received outpatient review in Fuwai Hospital from September 2015 to March 2016 after surgical treatment of CHDs were recruited in this study and 90 normal children were recruited as the control group. The children with CHDs were divided into simple CHDs group(RACHS-1 score≤2) and complex CHDs group(RACHS-1 score≥3) according to RACHS-1 classification. Neuropsychological development status was measured according to pediatric-psychological mental test scale developed by Capital institute of pediatrics, Beijing and statistical analysis was compared. Results The measurements of neuropsychological development showed the normal children behaved better than the children with CHDs(P<0.05). The simple CHDs group achieved better distribution of development quotient than complex CHDs group(P=0.032) and there was no difference between the normal control group and simple CHDs group(P=0.420). Multivariate regression analysis indicated that younger age at cardiac surgery, lower preoperative blood urea nitrogen(BUN), higher preoperative creatinine(Cr) and prolonged duration of cardiopulmonary bypass(CPB) accounted for lower scores in the test scale(P<0.05). Conclusion Distinct neuropsychological difficulties could be present especially in children with complex CHDs. Younger age at cardiac surgery, preoperative BUN, Cr and CPB duration were perioperative factors that were associated with long-time neuropsychological development. Key words: Congenital heart diseases; Child; Neuropsychological development; Cardiac surgery