Objective assessment of segmentation models for thyroid ultrasound images.

Abstract

Ultrasound features related to thyroid lesions structure, shape, volume, and margins are considered to determine cancer risk. Automatic segmentation of the thyroid lesion would allow the sonographic features to be estimated. On the basis of clinical ultrasonography B-mode scans, a multi-output CNN-based semantic segmentation is used to separate thyroid nodules' cystic & solid components. Semantic segmentation is an automatic technique that labels the ultrasound (US) pixels with an appropriate class or pixel category, i.e., belongs to a lesion or background. In the present study, encoder-decoder-based semantic segmentation models i.e. SegNet using VGG16, UNet, and Hybrid-UNet implemented for segmentation of thyroid US images. For this work, 820 thyroid US images are collected from the DDTI and ultrasoundcases.info (USC) datasets. These segmentation models were trained using a transfer learning approach with original and despeckled thyroid US images. The performance of segmentation models is evaluated by analyzing the overlap region between the true contour lesion marked by the radiologist and the lesion retrieved by the segmentation model. The mean intersection of union (mIoU), mean dice coefficient (mDC) metrics, TPR, TNR, FPR, and FNR metrics are used to measure performance. Based on the exhaustive experiments and performance evaluation parameters it is observed that the proposed Hybrid-UNet segmentation model segments thyroid nodules and cystic components effectively.