Abstract

Obesity is clearly associated with insulin resistance and chronic low-grade inflammation.1,2 Macrophages appear to be especially important in this relationship because they infiltrate adipose tissue and produce a variety of inflammatory cytokines.1 Exploring the contribution of other immune cells to the development of obesity, Liu et al3 described a role for mast cells in the development of obesity and diabetes in mice. Using genetically modified mice and pharmacologic stabilizers of mast cells, they demonstrated that mast cells and mast cell–mediated protease expression can promote the growth of white adipose tissue.

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