Abstract
Background: This review delves into the intricate relationship between obesity and COVID-19 severity, uncovering mechanistic insights such as immunological dysregulation, inflammation, and metabolic complexities. It addresses challenges in diagnosis and treatment, advocating for tailored approaches. Emphasis is placed on proper management and customized dietary interventions to mitigate severity. Methodology: Scientific data related to obesity and COVID-19 was obtained from data bases like PubMed, Scopus, google, and google scholar. The search words employed for the data search were “Mechanisms linking obesity and COVID-19”, “Inflammatory milieu,” “Immune dysregulation”, “Impact of obesity on COVID-19 Severity”, and “Dual relationship between obesity and COVID- 19”. Only relevant data related to the intricate relationship between obesity and COVID-19 severity and its management was included. Results: This paper explores the multifaceted mechanisms linking obesity to increased COVID-19 severity, including immunological dysregulation, inflammatory responses, and metabolic comorbidities. This review highlights complex problems that arise in the diagnosis and treatment of obese people with COVID-19. These problems range from precise diagnosis to individualized treatment plans. Management approaches for obese individuals with COVID-19 encompass lifestyle interventions, pharmacotherapy, and dietary considerations, each tailored to mitigate risks and improve outcomes. Additionally, treatment plans integrating multidisciplinary care, including personalized respiratory support, antiviral therapy, and thromboprophylaxis, are proposed to address the unique needs of obese patients battling COVID-19. Conclusion: The abstract underscores the complexity of this interaction, emphasizing the need for comprehensive information to guide clinical care and future research effectively.
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