Obesity and Breast Cancer Outcome: Adding to the Evidence

Abstract

tre, and active comparator controlled investigation of the effect of pioglitazone, metformin, and the combination of both on cardiovascular risk in patients with type 2 diabetes receiving stable basal insulin therapy: The PIOCOMB study. Cardiovasc Diabetol 10:65, 2011 26. Wanders D, Plaisance EP, Judd RL: Pharmacological effects of lipidlowering drugs on circulating adipokines. World J Diabetes 1:116-128, 2010 27. Banga A, Unal R, Tripathi P, et al: Adiponectin translation is increased by the PPARgamma agonists pioglitazone and omega-3 fatty acids. Am J Physiol Endocrinol Metab 296:E480-E489, 2009 28. Oki K, Koide J, Nakanishi S, et al: Fenofibrate increases high molecular weight adiponectin in subjects with hypertriglyceridemia. Endocr J 54:431-435, 2007 29. Storka A, Vojtassakova E, Mueller M, et al: Angiotensin inhibition stimulates PPARgamma and the release of visfatin. Eur J Clin Invest 38:820-826, 2008 30. Nakamura T, Kawachi K, Saito Y, et al: Effects of ARB or ACE-inhibitor administration on plasma levels of aldosterone and adiponectin in hypertension. Int Heart J 50:501-512, 2009 31. Aggarwal BB: Targeting inflammation-induced obesity and metabolic diseases by curcumin and other nutraceuticals. Annu Rev Nutr 30:173-199, 2010 32. Christodoulakos GE, Lambrinoudaki IV, Creatsa MG, et al: Circulating levels of atherogenesis-associated adipocytokines and apoptotic markers are differentially influenced by hormone therapy, tibolone and raloxifene in healthy postmenopausal women. Climacteric 11:155-165, 2008 33. Aguilar-Salinas CA, Garcia EG, Robles L, et al: High adiponectin concentrations are associated with the metabolically healthy obese phenotype. J Clin Endocrinol Metab 93:4075-4079, 2008 34. Inoue T, Kotooka N, Morooka T, et al: High molecular weight adiponectin as a predictor of long-term clinical outcome in patients with coronary artery disease. Am J Cardiol 100:569-574, 2007 35. Grossmann ME, Ray A, Dogan S, et al: Balance of adiponectin and leptin modulates breast cancer cell growth. Cell Res 18:1154-1156, 2008