O57-1 - The Assessment of Right Ventricular Function by Right Ventricular Stroke Work Index in Patients with Pre-Capillary Pulmonary Hypertension

Abstract

Background: Long-term outcomes of pre-capillary pulmonary hypertension (PH) have been improved. However, morbidity and mortality are still high because of right-sided heart failure (HF). Right-sided HF is closely related to right ventricular (RV) function such as RV stroke work index (RVSWI). The aim of this study was to compare clinical characteristics between low RVSWI and high RVSWI, and to investigate the association between low RVSWI and long-term outcomes in patients with pre-capillary PH. Methods: We included patients admitted to diagnose and evaluate PH by right heart catheterization between 2007 and 2015. Patients with pre-capillary PH were divided into 2 groups according to the median value of RVSWI (low RVSWI group: RVSWI < 19.7 gm/m2/beat; high RVSWI group: RVSWI > 19.7 gm/m2/beat). Multivariate Cox regression analysis were applied to investigate whether the low RVSWI were associated with HF death or HF readmission in patients with pre-capillary PH. Results: A total of 36 patients with pre-capillary PH were allocated into the low RVSWI group (n = 18) and high RVSWI group (n = 18). The low RVSWI group was significantly associated with HF death or HF readmission compared to the high RVSWI group even after adjusting for confounding factors (hazard ratio: 9.80 [95% CI: 1.15 to 83.85], P = .04). Conclusions: Lower RVSWI was significantly associated with HF death or HF readmission in patients with pre-capillary PH.