Abstract
Background: The pathophysiology of HFpEF remains poorly understood. Xanthine Oxidoreductase (XOR) plays a pivotal role in producing both uric acid and oxygen species (ROS). The relationship between plasma XOR activity and HFpEF has not been elucidated. Methods and Results: We measured XOR activity in 192 patients with HFpEF. Patients were divided into three groups, based on XOR activity. There were 51 major adverse cardiovascular events (MACEs) during a median follow-up period of 920 days. A multivariate Cox proportional hazard regression analysis showed that high XOR activity was significantly associated with MACEs after adjustment for confounding factors. Kaplan-Meier analysis revealed that high XOR activity was associated with the greatest risk for MACEs. Conclusions: High plasma XOR activity is associated with poor clinical outcomes in patients with HFpEF.
Published Version
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