O3-1-4 - Concentration of Blood Serum Melatonin in Patients with Simple and Complex Endometrial Hyperplasia

Abstract

Background: The pineal hormone melatonin is involved in the circadian regulation and facilitation of sleep, the inhibition of cancer development and growth, and the enhancement of immune function. Additionally, these individuals are not only immune suppressed, but they are also at an increased risk of developing a number of different types of cancerThe goal of the present work was to study the levels of blood serum melatonin in patients with simple and complex endometrial hyperplasia.Methods: A total of 24 patients (aged from 38 to 55 years) with Complex Endometrial Hyperplasia were studied. Control group was represented by 19 patients (aged from 37 to 62 years) with the with Simple Endometrial Hyperplasia. Plasma levels of melatonin were estimated by liquid chromatography.Results: The results showed that mean levels of melatonin were observed to be by 29,33% (p< 0,01) higher in patients with simple endometrial hyperplasia (without atypia) as compared to those with complex endometrial hyperplasia (without atypia). The study demonstrated that with complex hyperplasia (without atypia) mean levels of serum melatonin were moderately reduced in contrast to simple hyperplasia (without atypia), which confirms anti-proliferative and anti-cancer action of melatonin, since complex endometrial hyperplasia (without atypia) represents a pre-stage to atypical hyperplasia while the latter is a pre-cancer condition.Conclusions: The results suggest that in clinical practice, with simple and complex endometrial hyperplasia (without atypia) administration of melatonin as anti-proliferative and pro-apoptotic drug considerably hinders further progression of disease and, to a certain extent, has a preventive effect against the development of uterus body cancer.