Иммуногистохимические особенности гиперплазии эндометрия в условиях пре и постменопаузы при воздействии химических факторов

Abstract

Abstract. Objective: To study the frequency of endometrial hyperplasia in women with I-II degree obesity exposed to toxic-chemical factors, and to identify the most important immunohistochemical markers of the proliferative activity of endometrial cells. 60 women aged 45-65 years were examined, 30 of them worked in contact with a complex of toxic factors (the main group) and 30 – without them (the comparison group). The maximum single concentrations of toxicants exceeded the MPC by 2.1-5.4 times. The criterion of obesity was a BMI > 30.0. All underwent hysteroscopy and histological examination of scrapings. Immunohistochemical characteristics of the endometrial prescription apparatus were carried out by evaluating the proliferation marker Ki 67, estrogen (Eg) and progesterone receptors (Pr). Results. In all women, simple endometrial hyperplasia was most common, more often diagnosed in the main group in the presence of obesity and in the comparison group. The highest indicators of Ki 67 were found in workers of harmful production with complex and simple atypical endometrial hyperplasia in combination with obesity of I-II degree. Eg parameters were high in women of the main group with obesity, having complex atypical (71/48) and complex endometrial hyperplasia (66/30). Among the obese workers of the comparison group, high Eg values were found in simple and complex atypical hyperplasia (64/32 and 67/40, respectively). High values of Rg indicators in obese women who come into contact with chemical agents, who have complex (21/136) and simple atypical hyperplasia (26/124), as well as in obese workers of the comparison group and the presence of complex atypical hyperplasia (29/135). Conclusion. In women with endometrial hyperplasia, working