O-202 Phthalate Exposure And Child Development: The Polish Mother And Child Cohort Study

Abstract

article i nfo Background: Widespread phthalate exposure has prompted investigations concerning their potential adverse health effects. Aim:The objectiveof thisstudywastoevaluate the impactofpreandearlypostnatal phthalate exposureon child psychomotor development based on the data from the prospective Polish Mother and Child Cohort Study (REPRO PL). Studydesign,subjectsandoutcomemeasures:Phthalate exposurewasdeterminedbymeasuring11phthalate me- tabolites (MEP, MiBP, MnBP, 3OH-MnBP, MBzP, MEHP, 5OH-MEHP, 5oxo-MEHP, OH-MiNP, oxo-MiNP, and MnOP) in the urine collected from mothers during the third trimester of pregnancy (prenatal exposure) and from their children at the 24th month of age (postnatal exposure). The analysis was performed by the HPLC- MS/MS method. Psychomotor development was assessed in children at the age of 2 years by the Bayley Scales of Infant and Toddler Development. Results: Child motor development was inversely associated with natural log concentrations (μg/g creatinine) of 3OH-MnBP (β = −2.3; 95% CI −4.0 to −0.6), 5OH-MEHP (β = −1.2; 95% CI −2.2 to −0.3), 5oxo-MEHP (β = −1.8; 95% CI −3.3 to −0.2) and sum of DEHP metabolites (β = −2.2; 95% CI −3.6 to −0.8), DnBP metabolites (β = −1.9; 95% CI −3.4 to −0.4), and high molecular weight phthalates (β = −2.5; 95% CI −4.1 to −0.9) in the urine collected from mothers during pregnancy after adjustment for a variety of potential confounders. Addi- tional adjustment for postnatal phthalate exposure did not change the results. Postnatal child exposure to phthalates was not associated with any of the measured scores of child psychomotor development. Conclusions: The study findings add further support to the possibility that prenatal phthalate exposure may be det- rimental to child neurodevelopment and underscore the importance of policies and public health interventions aiming at reduction of such exposure.