Abstract
Responders to deep brain stimulation (DBS) in the subcallosal cingulate (SCC) share stimulation on a stereotypic connectome of converging white matter bundles. A tractography-based target selection using a “connectome blueprint” of past DBS responders shows improved results. While this structural pattern is a necessary requirement for antidepressant efficacy, there has been no functional evidence describing the distinction between effective and non-effective contacts.
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