Abstract
Background The habituation phenomenon is a frequency-dependent form of non-associative learning which reflects the excitability level of both sensory and pain systems. We previously demonstrated a frequency-dependent deficit of habituation of the conventional blink reflex in migraine[1]. We investigated the habituation of the trigeminal nociceptive system by studying the habituation of the late component (R2) of the nociceptive blink reflex (nBR) in a wide range of stimulation frequencies in subjects with migraine without aura (MWoA) and with aura (MWA).
Highlights
The habituation phenomenon is a frequency-dependent form of non-associative learning which reflects the excitability level of both sensory and pain systems
We investigated the habituation of the trigeminal nociceptive system by studying the habituation of the late component (R2) of the nociceptive blink reflex in a wide range of stimulation frequencies in subjects with migraine without aura (MWoA) and with aura (MWA)
We studied, interictally, 25 MWoA and 17 MWA subjects, as well as 20 healthy control subjects
Summary
The habituation phenomenon is a frequency-dependent form of non-associative learning which reflects the excitability level of both sensory and pain systems. We previously demonstrated a frequency-dependent deficit of habituation of the conventional blink reflex in migraine[1]. We investigated the habituation of the trigeminal nociceptive system by studying the habituation of the late component (R2) of the nociceptive blink reflex (nBR) in a wide range of stimulation frequencies in subjects with migraine without aura (MWoA) and with aura (MWA)
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