Abstract
ObjectiveTo identify a relationship between antidepressant medication use and impaired semen parameters in a subset of male infertility patients.DesignCase report.Materials and methodsWe have identified two patients who have had severely impaired sperm concentration and motility closely associated with the use of antidepressant medications. We describe the temporal association between abnormal semen parameters and antidepressant therapy in these two patients (who had normal semen parameters off of any medication) and were identified during evaluation for male infertility.ResultsView Large Image Figure ViewerDownload (PPT)ConclusionMedications used for the treatment of depression may have a negative, reversible effect on male fertility. Serotonin-reuptake inhibitor antidepressants may affect sperm transport, resulting in impaired sperm motility and concentration for some patients. Further controlled studies of the effect of serotonin reuptake inhibitors on semen parameters are warranted to identify the clinically significant frequency of this effect. ObjectiveTo identify a relationship between antidepressant medication use and impaired semen parameters in a subset of male infertility patients. To identify a relationship between antidepressant medication use and impaired semen parameters in a subset of male infertility patients. DesignCase report. Case report. Materials and methodsWe have identified two patients who have had severely impaired sperm concentration and motility closely associated with the use of antidepressant medications. We describe the temporal association between abnormal semen parameters and antidepressant therapy in these two patients (who had normal semen parameters off of any medication) and were identified during evaluation for male infertility. We have identified two patients who have had severely impaired sperm concentration and motility closely associated with the use of antidepressant medications. We describe the temporal association between abnormal semen parameters and antidepressant therapy in these two patients (who had normal semen parameters off of any medication) and were identified during evaluation for male infertility. Results ConclusionMedications used for the treatment of depression may have a negative, reversible effect on male fertility. Serotonin-reuptake inhibitor antidepressants may affect sperm transport, resulting in impaired sperm motility and concentration for some patients. Further controlled studies of the effect of serotonin reuptake inhibitors on semen parameters are warranted to identify the clinically significant frequency of this effect. Medications used for the treatment of depression may have a negative, reversible effect on male fertility. Serotonin-reuptake inhibitor antidepressants may affect sperm transport, resulting in impaired sperm motility and concentration for some patients. Further controlled studies of the effect of serotonin reuptake inhibitors on semen parameters are warranted to identify the clinically significant frequency of this effect.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
