Abstract
Aim . To study characteristic features of nutritional status of patients with Wilson ’s disease depending on stage of liver damage and determine the impact of malnutrition on oxidative stress level. Methods . The study included 73 subjects, 33 (15 men and 18 women) had a confi rmed diagnosis of Wilson’s disease. All patients with Wilson’s disease (the study group) had liver damage: non-cirrhotic stages — 12 (36.3%), cirrhosis — 21 (63.6%). The control group consisted of 40 healthy subjects (20 men and 20 women) with neither body weight defi ciency, nor obesity, nor liver disease. All patients were conducted standard blood tests (clinical and biochemical blood tests), measuring malonodialdehyde (MDA) in blood serum by high-performance liquid chromatography, as well as assessment of height, weight and BMI (Body Mass Index) and analysis the body mass composition with bioelectricalimpedanceanalyzer “Diamant AIST”. Results . 1. Malnutrition was more common among patients with liver cirrhosis (28.6%) than in patients with non-cirrhotic stages (8.3%). 2. The nutritional status of patients with liver cirrhosis was signifi cantly diff erent from the control group: BMI, total protein and albumin levels, lymphocytes and arm muscular circumference were signifi cantly lower in patients with liver cirrhosis compared to the control group. The decrease in fat and muscular mass was more pronounced among women than men with liver cirrhosis. 3. The group of patients with chronic hepatitis did not significantly statistically diff er from the control group in most nutritional status parameters, except for albumin level, which was signifi cantly lower in persons of both sexes with noncirrhotic stages; total protein level and body fat percent were signifi cantly higher in men with non-cirrhotic stages than in the control group. 4. The marker of oxidative stress level was signifi cantly higher in patients with liver cirrhosis, and was higher in patients with malnutrition.
Highlights
Malnutrition was more common among patients with liver cirrhosis (28.6%) than in patients with non-cirrhotic stages (8.3%)
The nutritional status of patients with liver cirrhosis was significantly different from the control group: BMI, total protein and albumin levels, lymphocytes and arm muscular circumference were significantly lower in patients with liver cirrhosis compared to the control group
The group of patients with chronic hepatitis did not significantly statistically differ from the control group in most nutritional status parameters, except for albumin level, which was significantly lower in persons of both sexes with noncirrhotic stages; total protein level and body fat percent were significantly higher in men with non-cirrhotic stages than in the control group
Summary
The study included 73 subjects, 33 (15 men and 18 women) had a confirmed diagnosis of Wilson’s disease. All patients with Wilson’s disease (the study group) had liver damage: non-cirrhotic stages — 12 (36.3%), cirrhosis — 21 (63.6%). The control group consisted of 40 healthy subjects (20 men and 20 women) with neither body weight deficiency, nor obesity, nor liver disease. All patients were conducted standard blood tests (clinical and biochemical blood tests), measuring malonodialdehyde (MDA) in blood serum by high-performance liquid chromatography, as well as assessment of height, weight and BMI (Body Mass Index) and analysis the body mass composition with bioelectricalimpedanceanalyzer “Diamant AIST”
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