Clinical and laboratory features in pregnant women with body weight deficiency

Abstract

In recent years, endocrinopathy, in particular, and body weight deficiency have taken an important place in the structure of genital and extragenital pathology. Background somatic diseases are a risk factor for pregnancy loss, but the detailed mechanisms of influence on the course of pregnancy and childbirth in patients with body weight deficiency have not been studied. The objective: to evaluate the clinical and laboratory parameters of pregnant women with body weight deficiency. Materials and methods. A clinical, laboratory and functional examination of 200 pregnant women with body weight deficiency and 30 pregnant women with normal body weight was carried out. Body mass index (BMI) was calculated according to A. Ketle formula. Results. In women with body weight deficiency before pregnancy, the reduction in nutrition (BMI 19.1±0.4 kg/m2) was 50%, hypotrophy of the I degree (BMI 18.0±0.5 kg/m2) – 41% and hypotrophy of the II–III degrees (BMI 16.3±0.9 kg/m2) – 9%. It was established that the total frequency of genital pathology before pregnancy in women with a body weight deficiency was 51.5%, among which menstrual cycle disorders predominated (16.5%). It was found that in pregnant women with a body weight deficiency, the increase in body weight occurs mainly (70–80%) due to lean body mass. During the assessment of clinical and biochemical indicators, no significant differences were found in the levels of hemoglobin, glucose, total protein and blood cholesterol compared to the indicators of women with normal body weight. However, a high frequency of hypocalcemia (71.7–92.8%), which correlates with the degree of hypotrophy, was found in women with body weight deficiency.Conclusions. Pregnant women with body weight deficiency are characterized by a high cumulative frequency of genital pathology before pregnancy, the absence of reliable changes in the levels of hemoglobin, glucose, total protein and blood cholesterol, and the presence of hypocalcemia.