Abstract
Nutritional status modulates immune response to infections and can alter risk of infectious diseases, including tuberculosis. We assessed correlations between nutritional status indicators (micronutrient serum biomarkers; anthropometry) and latent tuberculosis infection (LTBI) among participants of the National Health and Nutrition Examination Survey (NHANES) 1999–2000 (n=7386). LTBI was evaluated by mean induration in response to tuberculin skin test (TST). LTBI prevalence was 4.2%, as previously reported (5.1% males, 3.2% females). Positive TST was observed in 0.8% of individuals with low (<10th percentile), 4.0% of those with normal (10–75th percentile), and 5.8% of those with high (>;75th percentile) subscapular skinfold thickness. >; 75th percentile subscapular skinfold thickness was associated with positive TST (>;1.5‐fold increased odds), adjusting for known sociodemographic and health‐related risk factors, including foreign birth, household contact with TB case, and BCG scar. Available micronutrient serum biomarker levels and mid‐upper arm circumference were not associated with TST (p>;0.05), controlling for covariates. Smoking was also positively associated with LTBI (OR 2.09, 95% CI: 1.40–3.11).Grant Funding Source: None
Published Version
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