Abstract
BackgroundThe pathogenesis and prognosis of multiple sclerosis (MS) is an area of active medical research. Dietary and biochemical parameters such as serum 25-dihydroxycholecalciferol, magnesium, and potassium play a role in disease progression. This study aimed to compare the nutritional status and biochemical profile of patients with and without MS.MethodologyThis case-control study included a total of 112 participants (56 in the control group and 56 in the MS group). The participants’ socioeconomic and demographic profiles, nutritional status, and biochemical details were all gathered using history, patient files, and records. The effect of these parameters on the presence of MS was evaluated using a decision tree model. Student’s t-test and Mann-Whitney U test were performed to compare these parameters.ResultsA decision tree model was developed with an accuracy rate of 86.52%. The vitamin and mineral intake of the groups showed significant statistical differences (p = 0.001). The differences were important in terms of biochemical parameters, especially serum levels of 25-dihydroxycholecalciferol and potassium.ConclusionsThe key parameters that varied between MS patients and the control group, according to the constructed decision tree, were serum levels of 25-dihydroxycholecalciferol, magnesium, calcium, potassium, and carbohydrate intake. Nutritional measures against MS can be taken based on the decision tree.
Highlights
Multiple sclerosis (MS) is a steadily progressing disorder of the central nervous system marked by demyelinating brain and spinal cord regions [1]
Dietary and biochemical parameters such as serum 25-dihydroxycholecalciferol, magnesium, and potassium play a role in disease progression
The differences were important in terms of biochemical parameters, especially serum levels of 25-dihydroxycholecalciferol and potassium
Summary
Multiple sclerosis (MS) is a steadily progressing disorder of the central nervous system marked by demyelinating brain and spinal cord regions [1]. Smoking has been proven to be a major etiological factor that contributes to the development and progression of the disease [4]. There is no proven cure for MS as there is much to be researched regarding the disease etiology, pathogenesis, and treatment. Calcium is a mineral that is essential for nerve conduction control, cell membrane stabilization, and aids in nerve impulses communication which can slow the onset or even prevent the disease [6]. Dietary and biochemical parameters such as serum 25-dihydroxycholecalciferol, magnesium, and potassium play a role in disease progression.
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