Abstract
NUT carcinoma is an aggressive carcinoma with an overall poor survival outcome. The mediastinum and head and neck area, especially the sinonasal region, are among the common sites of disease. Histopathological diagnosis of NUT carcinoma is often very challenging due to its overlapping features with other poorly differentiated carcinomas. We report a case of NUT carcinoma arising from the parotid gland of a young female patient. Primary NUT carcinoma of salivary gland is very rare, with only 15 such cases reported in the literature to date. Our case highlights the diagnostic challenges associated with such lesions.
Highlights
NUT carcinoma is a rare, poorly differentiated carcinoma characterised by a genomic rearrangement of the nuclear protein of testis (NUT) gene, with BRD4-NUT being the most common fusion variant
Diagnosis is likely to be challenging on core biopsy material, which may not be representative of the complete morphology and architecture of the neoplasm
Primary NUT carcinoma originating from the salivary glands is very rare and a diagnostic challenge
Summary
NUT carcinoma is a rare, poorly differentiated carcinoma characterised by a genomic rearrangement of the nuclear protein of testis (NUT) gene, with BRD4-NUT being the most common fusion variant It generally arises from the mediastinum, but numerous cases involving the head and neck, mainly from the sinonasal region, have been reported [1,2,3,4,5]. MRI and Computerized tomography (CT) imaging demonstrated a recurrent lesion in the left parotid region, accompanied by widespread metastatic disease in the spine and skull base (Fig. 1). Following this recurrence, the pathology was reviewed at a tertiary specialist oral and maxillofacial pathology department. The patient died of progressive and widespread metastatic disease from the original salivary lesion within six months of diagnosis
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