NUMERICAL STUDY ON THE EFFECTS OF THE NUMBER AND GEOMETRIES OF DRUG-ELUTING STENT LINKS ON THE DRUG CONCENTRATION

Abstract

The paper investigated the effects of the link numbers and geometries of drug-eluting stents (DESs) on the hemodynamics and the distribution of drug concentration, and the final results could be used as a guide for the optimization of DES design. Four 3D virtual stents with different numbers and geometries of links were modeled and numerically studied with respect to the distribution of wall shear stress (WSS) and drug concentration. Results have showed (1) The geometries of links have big impact on the distribution of WSS regions and the uniform drug concentration distribution on the vascular wall, but little effect on the mean drug concentration on the vascular wall; the S-shaped link stents had less low-WSS regions and the reason is that the flow direction was considered in the design of this type of stents. (2) The drug concentration distribution on the vascular wall had remarkable difference from that in blood. (3) The 6S link stent had the least low-WSS regions and with high and uniformly distributed drug concentration, so this type of stent was concluded to be the best design in four stents. Overall, it is not reliable to use the drug concentration in blood to deduce the drug concentration on the vascular wall. In DES design, the configuration of links should be, as much as possible, in line with the blood flow direction, so it can decrease the low-WSS regions. Meanwhile, in order to get more uniformly distributed drug on the vascular wall, the distribution of drug on the stent surface should be taken into account. Additionally, because of the increment of contact area between the stents and vascular wall, the drug concentration on the vascular wall increased with the number of links.