Abstract
This work investigates how the configuration of the geometric parameters of a radial crystallizer influences the results of the crystallization of lovastatin by antisolvent and using a multi-scale computational fluid dynamics (CFD) model. The OPENFOAM open-source software uses macro and micromixing expressions for flow, and complete energy and population equilibrium equations during nucleation and crystal growth. The model is based on the Reynolds-Averaged-Navier-Stokes (RANS) equation, along with a multi-environment probability density function (PDF) model and the spatially semi-discretized population equilibrium equation, operating a high-resolution finite volume method. The variation crystallizer construction parameters provided another crystallizer design, and analyses demonstrated improved performance and effects on crystal distribution.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.