Abstract
In this paper, we present a modified density-dependent Drucker-Prager Cap (DPC) model with a nonlinear elasticity law developed to describe the compaction behavior of pharmaceutical powders. The model is implemented in ABAQUS with a user subroutine. Using microcrystalline cellulose (MCC) Avicel PH101 as an example, the modified DPC model is calibrated and used for finite element simulations of uniaxial single-ended compaction in a cylindrical die. To validate the proposed model, finite element simulation results of powder compaction are compared with experimental results. It was found that finite element analyses gave a good prediction of both the loading-unloading curves during powder compaction and the compaction force required for making a tablet with a specified density. Further, the failure mechanisms of chipping, lamination and capping during tabletting are investigated by analysing the stress and density distributions of powders during the three different phases of the tabletting processes, i.e. compression, decompression and ejection. The results indicate that the model has excellent potential to describe the compaction process for generic pharmaceutical powders.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.