Abstract
Chemotherapy kills the cancer cells by disrupting cell division. Although chemotherapy is an efficient treatment of cancer, it has many side effects since drugs circulate throughout the body. A promising approach to reduce these side effects is targeted drug delivery. The present study investigates the capture efficiency of carrier particles in a Y-shaped vessel under the effect of an external magnetic field produced by a current-carrying wire. Different parameters including magnetic, drag, buoyancy, and Lorentz forces have been considered. In addition, the effect of particle-particle interaction and non-Newtonian behavior of blood have been included. The generalized power-law (GPL) and modified Casson models are used for modeling non-Newtonian behavior. Results show that capture efficiency (CE) is increased as the blood velocity and the particle diameter are reduced and increased, respectively. Besides, it was found that considering particle-particle interaction has led to a reduction in CE in all cases. For example, the CE of nanoparticles for the case without interaction force is 51.66%, while for the case with interaction force is 43.33%, showing a nearly 16% reduction. Besides, it was observed that modified Casson provides a more accurate prediction for blood behavior than the GPL model.
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