Numerical analysis of non-Fourier thermal response of lung tissue based on experimental data with application in laser therapy

Abstract

Background and objectiveThe thermal therapy is a minimally invasive technique used as an alternative approach to conventional cancer treatments. There is an increasing concern about the accuracy of the thermal simulation during the process of tumor ablation. This study is aimed at investigating the effect of finite speed of heat propagation in the biological lung tissue, experimentally and numerically. MethodsIn the experimental study, a boundary heat flux is applied to the lung tissue specimens and the temperature variation is measured during a transient heat transfer procedure. In the numerical study, a code is developed based on the finite volume method to solve the classical bio-heat transfer, the Cattaneo and Vernotte, and the Dual-phase-lag (DPL) equations. The thermal response of tissue during the experiments is compared with the predictions of the three heat transfer models. ResultsIt is found that the trend of temperature variation by the DPL model resembles the experimental results. The experimental observation in parallel with the numerical results reveals that the accumulated thermal energy diffuses to the surrounding tissue with a slower rate in comparison with the conventional bio-heat transfer model. The DPL model is implemented to study the temperature elevation in the laser irradiation to lung tissue in the presence of gold nanoparticles (GNPs). It is concluded that the extent of the necrotic tumoral region and the area of the damaged healthy tissue are reduced, when the non-Fourier heat transfer is taken into account. ConclusionsResults show that considering the phase lags is crucial in planning for an effective thermal treatment, in which the cancerous tissue is ablated and the surrounding tissues are preserved from irreversible thermal damage.