Numerical analysis of magnetic nanoparticle transport in microfluidic systems under the influence of permanent magnets

Abstract

A finite element technique was employed for analysing the transport behaviour of magnetic nanoparticles (MNPs) under the gradient magnetic field generated by rectangular permanent magnets with different configurations. To predict the exact particle dynamic behaviour, the governing non-linear differential equations, Navier–Stokes and convection–diffusion were coupled with the magnetic field equation. The MNP concentration distribution was calculated and taken as an evaluation parameter to show where MNPs are preferentially captured in a microchannel. Since the dynamic behaviour of MNPs in the flow was dependent on the competition between magnetic and fluidic forces, the effects of the flow velocity and magnetic field strength on the MNP concentration distribution were analysed. Meanwhile, the effects of magnetic design parameters for permanent magnets on the magnetic force and MNP concentration distribution were analysed. Results showed that the MNP concentration in the capture region increased with magnetic field strength and decreased with increasing flow velocity. And the shape and position of the high concentration regions were related to the applied inlet velocity, magnetic field strength, geometry of the magnets and the orientation of the remanent flux density. The simulations performed can be used as a tool for the design and optimization of millimetre-sized rectangular magnets for developing efficient lab-on-a-chip systems.