Abstract
Actin dynamics is one of the essential mechanisms for cell movements. Recent studies revealed various proteins required to control actin dynamics in cells, i.e. G-actin for actin assembly and disassembly, Arp2/3 for branching of actin filament, ADF/cofilin for severing of actin filament, capping protein for terminating actin filament elongation and so on. Based on those proteins’ regulatory control, dendritic actin networks would be formed close to the edge of the cell, which leads to the cell protrution, that is the first step of the cell movements. However, because of the difficulty in measuring the actin network dynamics in living cell, it is still unclear how the actin network is remodeled dynamically inside the cell. Therefore, in this study, we developed a computational stochastic model based on chemical reaction equations for the dendritic nucleation model of the actin dynamics using Gillespie's algorithm. In the analysis, local concentration of proteins, rate constant of chemical reaction equations and mechanical relationship between the actin network inside the cell and cell membrane were taken into consideration, and the mechanism of the cell protrution was analyzed.
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