Number 2 Feibi Recipe Reduces PM2.5-Induced Lung Injury in Rats.

Zhaoheng Liu,Yang Jiao,Shuo Liu,Fang Cao,Guodong Li,Xinxin Zou,Wei Wang,Haojie Yang

doi:10.1155/2018/3674145

Abstract

Air pollution is the main cause of respiratory diseases. Fine particulates with the diameter below 2.5 μm can get into the alveoli and then enter the blood circulation through the lung tissue ventilation function and cause multiple systemic diseases especially the respiratory diseases. This study investigated the pathological mechanism of the lungs injury in rats induced by PM2.5 and the effect and mechanism of the Chinese herbal medicine number 2 Feibi Recipe (number 2 FBR) on lungs injury. In this experiment, Wistar rats were used. Lungs injury was induced by PM2.5. Number 2 FBR was used to treat the rats. The result showed that number 2 FBR could improve the lung injury in the rats. Meanwhile, it significantly reduced pathological response and inflammatory mediators including interleukin-6 (IL-6), interleukin-13 (IL-13), interleukin-17 (IL17), monocyte chemotactic protein-1 (MCP-1), and transforming growth factor-α (TNF-α) and upregulated glutathione peroxidase (GSH-Px) in the PM2.5 induced lung injury in the rats. Collectively, number 2 FBR appears to attenuate the lungs injury in rats induced by PM2.5.

Highlights

Air pollution is the problem that human beings are facing these days and it is becoming one of the main causes of respiratory diseases
As for fine particulates with the diameter below 2.5 μm, they can go through the human defense barrier to enter the alveoli and enter the blood circulation through the lung tissue ventilation function
The levels of IL-6, IL-13, IL-17, monocyte chemotactic protein-1 (MCP-1), and transforming growth factor-α (TNF-α) were greater in model group and number 2 FBR group with statistical difference (P < 0.05)

Summary

Introduction

Air pollution is the problem that human beings are facing these days and it is becoming one of the main causes of respiratory diseases. As for fine particulates with the diameter below 2.5 μm, they can go through the human defense barrier to enter the alveoli and enter the blood circulation through the lung tissue ventilation function. It can cause multiple systemic diseases, such as asthma, bronchus inflammation, pulmonary fibrosis, chronic obstructive pulmonary disease, and even lung cancer and other respiratory diseases [1]. According to the characteristics of PM2.5 induced lungs injury, we modified this formula as number 2 FBR and used it to treat the PM2.5 model rats to observe the difference in sham, model, and number 2 FBR groups

Material and Method

Results

Discussion

Conclusion