Nucleophilic substitution of the nitro group in 1-substituted 3-nitro-1H-1,2,4-triazoles in ethanolic potassium hydroxide

Abstract

Dehydrochlorination of 1-(2-chloroethyl)-3-nitro-1H-1,2,4-triazole in ethanolic potassium hydroxide is accompanied by nucleophilic substitution of the nitro group by the ethoxy group. The same nucleophilic exchange in 1-substituted 3-nitro-1H-1,2,4-triazoles occurs in methanol and n-propanol solutions of potassium hydroxide.