Nucleic acids and their components in tumor-bearing mice during growth and regression of tumors.

Abstract

Summary1. The concentration of ribose nucleic acid (RNA), desoxyribose nucleic acid (DNA), adenine, and guanine of liver, lung, kidney, and spleen of normal C3H mice and those bearing a transplantable mouse lymphosarcoma at different stages of tumor development has been determined. The mice bearing the tumor were divided into 2 groups; one group received desoxypyridoxine on a vit. B6 deficient diet, while the other received desoxypyridoxine on a diet rich in vit. B6 to counteract the effect of the anti-vitamin. In addition to DNA, RNA, adenine, and guanine, the pyrimidines (uracil, cytosine, and thymine) were also determined in the spleen. 2. The data presented indicate that there is an increase in the nucleic acids and their purine constituents in the liver, kidney, and lung during the growth of the tumor. 3. The nucleic acids reached a higher level in mice receiving desoxypyridoxine on a vit. B6 sufficient diet than in mice receiving desoxypyridoxine on a vit. B6 deficient diet. 4. Mice receiving desoxy...