Abstract
Rats grown on a diet deficient in choline had normal liver DNA values for the first 7 weeks after the removal of choline from the diet. At the 12th week the liver DNA level was 20% higher than the liver DNA level in the control group. By the 22nd week the level of liver DNA was 50% higher than control rats and remained at this high level for the remainder of the experiment. The level of RNA in the liver of the choline-deficient group was lower than the level of the liver RNA of the control group during this period. Rats fed a basal diet containing 0.2% ethionine, 0.1% methionine, and 0.2% choline had normal liver DNA values for the first 3 weeks. By the 4th week the level of liver DNA was 60% higher than that of the control group and remained at a high level for the remainder of the experiment. When the choline and methionine levels of the ethionine-containing diet were increased to 0.6%, liver DNA values were comparable to those of controls.
Published Version
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