Abstract
Malpighian tubules of Triatoma infestans cultivated in vitro in presence of 0.05 mM sodium valproate (VPA) for 1-4 h had their nuclear phenotypes investigated regarding induction of chromatin remodeling. Under present conditions, although a few nuclei demonstrated heterochromatin decondensation, no overall differences resulted in comparison to tests in which live insects are injected with VPA.
Highlights
Valproic acid/sodium valproate (VPA), an anticonvulsant widely prescribed for treatment of seizure disorders, is a well-known histone deacetylase inhibitor and a chromatin remodeling agent[1,2]
Considering the hypothesis that the drugs injection may not result totally effective to reach the cells in this work we examined the nuclear phenotypes of T. infestans Malpighian tubules cultivated in vitro in presence of VPA
Malpighian tubules removed from 5th instar nymphs of T. infestans (Klug) supplied by SUCEN (Mogi-Guaçu, SP) were cultivated for 1 to 4 h in the Leibovitz L-15 medium
Summary
Valproic acid/sodium valproate (VPA), an anticonvulsant widely prescribed for treatment of seizure disorders, is a well-known histone deacetylase inhibitor and a chromatin remodeling agent[1,2]. Nuclear phenotypes of Triatoma infestans Malpighian tubules cultivated in vitro in presence of sodium valproate Malpighian tubules of T. infestans cultivated in vitro in presence of 0.05 mM sodium valproate (VPA) for 1-4 h had their nuclear phenotypes investigated regarding induction of chromatin remodeling.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Revista dos Trabalhos de Iniciação Científica da UNICAMP
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
