Abstract
The ATP utilized in metabolic reactions within the nucleus is produced exclusively in the nucleus by glycolysis and oxidative phosphorylation. When the concentration of ATP per se is measured it was found to decrease after a short period of time probably due to its breakdown by phosphatases or its utilization by synthetic reactions. When a suitable trapping system was employed it was found that the nucleus could sustain a measurable synthesis of ATP for several hours. “ATP energy” can probably be stored in the form of polyphosphates under certain conditions of metabolic inactivity. A number of compounds were found to affect the synthesis of nuclear acid-soluble organic phosphates. The relationship of these and other compounds to nuclear phosphorylation is discussed.
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