Abstract
Nuclear factor erythroid 2-related factor 2 (Nrf2) activators,with Nrf2 as their target,exert antioxidant activity,and have become one of the most important antioxidants.They may activate Nrf2/Keapl system directly or indirectly,induce the expression of antioxidant genes and phase Ⅱ enzyme genes,increase the antioxidant ability of cells,and hence,play important roles in cellular protection and defense.Recently,numerous studies in vivo and in vitro have demonstrated that Nrf2 activators,such as (-)-epigallocatechin-3-gallate,curcumin,sulforaphane and aspirin,have a favorable efficacy in the management of sun damage,vitiligo,bullous dermatoses,wound healing,skin tumors,chloasma,psoriasis,and so on. Key words: Skin diseases; Nrf2 activators; Therapy
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