Abstract
The use of indoor tanning beds for cosmetic purposes has been very popular among the Caucasian population in the US. It is estimated that almost one in three Caucasian women aged 16 to 25 years use indoor tanning devices each year. Indoor tanning beds produce concentrated UV-A and UV-B rays and can be more harmful than the natural rays of the sun. The International Agency for Research on Cancer classified UV-emitting tanning devices as group 1 carcinogens in 2009. UV exposure from sunlight and indoor tanning bed has been linked to the risk of melanoma and non-melanoma skin cancers. Although the incidence rate of melanoma is higher among men than women, melanoma is more common among women among those aged 50 years or younger, which can be, at least partially, attributed to the use of indoor tanning beds. Recently, it has been reported that volunteers subjected to UV light and treated with sulforaphane showed a decrease in the development of skin erythema. Sulforaphane is a natural compound that is present abundantly in broccoli and broccoli sprouts. Commercially available sulforaphane supplements have been demonstrated to be safe and lack of toxicity. Data indicates that sulforaphane has anti-cancerous activity via a reduction of glutathione levels, which is regulated by nuclear factor erythroid 2-related factor-2 (Nrf2). The knowledge gained so far may present a unique opportunity for chemoprevention trials examining the efficacy of sulforaphane in melanoma prevention. Well-planned and well-characterized trials examining molecular pathways could also further our understanding of the carcinogenic mechanisms for melanoma.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.