NÖTROFİL LENFOSİT VE PLATELET LENFOSİT ORANLARININ AKTİF BEHÇET HASTALARINDAKİ ÖNEMİ

Abstract

NOTROFIL LENFOSIT VE PLATELET LENFOSIT ORANLARININ AKTIF BEHCET HASTALARINDAKI ONEMI Ozet Amac: Behcet Hastaligi; otoimmun, inflamatuar ve sistemik bir hastaliktir. Hastaligin klasik triadi; oral aft, genital ulser ve uveittir.  Bu calismanin amaci; C-reaktif protein (CRP), eritrosit sedimentasyon hizi (ESR), notrofil lenfosit orani (NLO), platelet lenfosit orani (PLO), platelet sayisi (PLT) ve ortalama platelet hacmi (MPV) ile sistemik inflamatuar bir hastalik olan Behcet arasindaki iliskinin ortaya konulmasi amaclanmistir. Yontemler: Calismaya Ocak 2014-Eylul 2015 tarihleri arasinda, uluslararasi siniflandirma kriterlerine uygun olarak Behcet Hastaligi tanisi almis 53 hasta ve 55 saglikli olgu alindi. Behcet hastalari aktif (n=20) ve inaktif (n=33) olarak iki gruba ayrildi. CRP, ESR, WBC, PLT, MPV degerleri kaydedildi, NLO ve PLO degerleri hesaplandi. Bulgular: Aktif Behcet’li hastalarda CRP, ESR, WBC, PLT, MPV, NLO ve PLO degerlerinin olculdugu Receiver operating characteristic egrisi degerlendirmesinde en yuksek AUC degeri CRP’de tespit edilirken (Egri altindaki alan (AUC):0.964) sonraki AUC degerleri ESR (AUC:0,849), WBC (AUC:0,849), NLO (AUC:0,816), PLO (AUC:0,661), PLT (AUC:0,654) ve MPV (AUC:0,524) olarak gozlenmistir. Sonuc: Bu sonuclar; NLO, PLO ve PLT degerlerinin CRP, ESR ve WBC gibi Behcet Hastaligi’nin aktif donemini ongormede kullanilabilecegi buna karsin MPV’nin kullanilamayacagini ortaya koymaktadir. Anahtar kelimeler: Behcet Hastaligi; Notrofil Lenfosit Orani; Platelet Lenfosit Orani The Importance of Neutrophil to Lymphocyte and Platelet to Lymphocyte Ratios in Active Behcet Disease Abstract Objective: Behcet Disease; is an autoimmune, inflammatory and systemic diseases. Classic triad of the disease are oral ulcers, genital ulcers and uveitis. The aim of this study is to reveal the relationship between C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), platelet (PLT) and mean platelet volume (MPV) and Behcet which is a systemic inflammatory disease. Methods: Fifty-three patients who were diagnosed by the international diagnostic criteria of Behcet Disease; and 55 healthy subjects were enrolled in the study, between January 2014 and October 2015. Behcet Disease patients were divided into two groups: active (n=20) and inactive (n=33). CRP, ESR, WBC, PLT, MPV were recorded, NLR and PLR was calculated. Results: An evaluation of the Receiver operating characteristic curves for the CRP, ESR, WBC, PLT, MPV, NLR and PLR values measured at active Behcet Disease patients indicated that the CRP value had the highest (Area Under Curve (AUC):0.964), while the next highest AUC values were observed with ESR (AUC:0,849), WBC (AUC:0,849), NLR (AUC:0,816), PLR (AUC:0,661), PLT (AUC:0,654) and MPV (AUC:0,524). Conclusion: These findings suggest that NLR, PLR and PLT levels can be used to predict the period of active Behcet Disease like CRP, ESR and WBC whereas MPV levels can not be used. Keywords: Behcet Disease; Neutrophil to Lymphocyte Ratio; Platelet to Lymphocyte Ratio