Abstract
NRAMP1 Gene Polymorphism and Susceptibility to Cutaneous Leishmaniasis in Iraq
Highlights
Cutaneous leishmaniasis (CL), a vector-borne disease caused by obligate intra-macrophage protozoa, transmitted by the species of phlebotomine sandflies, and characterized by diversity and complexity [1]
There was a significant difference found in G and A allele between patients and healthy controls; data in the present study revealed higher frequency of allele A in controls than in the CL patients, as of 31.25% and 15%, respectively (p = 0.01)
Genetic factors play a crucial role in host susceptibility or resistance to infectious diseases; variations within the Natural resistance-associated macrophage protein 1 (NRAMP1) gene were assessed in this study with respect to CL in Al-Muthama province, Iraq which has not been reported before from this region
Summary
Cutaneous leishmaniasis (CL), a vector-borne disease caused by obligate intra-macrophage protozoa, transmitted by the species of phlebotomine sandflies, and characterized by diversity and complexity [1]. Natural resistance-associated macrophage protein 1 (NRAMP1) gene is an important member of the solute carrier family 11 and called SLC11A1 [4]. The control group included 32 apparently healthy individuals; their mean age was 21 ± 9 years old, including 18 males and 14 females.
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