Abstract
Double immunolabelling immunohistochemistry in the arcuate nucleus of the rat demonstrates that neuropeptide Y (NPY) Y1 receptor like immunoreactivity of β-endorphin is strongly present in a subpopulation β-endorphin immunoreactive nerve cell bodies, while the small NPY immunoreactive nerve cell bodies lie in an arcuate area rich in NPY immunoreactive nerve terminals forming an uniform plexus. It is postulated that NPY Y1 receptors in β-endorphin neurons may mediate some actions of NPY on motivational processes and pain control as well as on hypophyseal hormone secretion, involving at least in part a regulation of the tubero-infundibular dopamine (DA) neurons.
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