Abstract
Patients with connective tissue disease (CTD) often suffer from facial cutaneous defects and resultant facial asymmetry. Unfortunately, these issues have been known to be difficult-to-treat, and concern exists regarding the use of cosmetic procedures in this patient population due to the theoretical risk of disease flare-up or reactivation. Injectable poly-L-lactic acid (PLLA) is one type of filler that has been used to treat skin atrophy in patients with morphea and lupus erythematous panniculitis. However, overall, there is a dearth in literature regarding the safety and efficacy of PLLA filler in patients with CTDs. This case series intends to evaluate the safety and efficacy of PLLA filler in treating facial atrophy in patients with CTDs. Three patients underwent various treatment courses involving the use of PLLA filler to treat facial atrophy. Two patients demonstrated significant improvement in facial atrophy following their treatment course. No patient experienced reactivation or exacerbation of their CTD following PLLA injection. PLLA filler appears to have good viability as a safe and potentially effective treatment for facial atrophy in patients with CTDs.
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